Blogs

The October 2024 issue of Toxicological Sciences includes an In-Depth Review article that presents existing evidence on the potential toxicity resulting from humectants, sugars, and flavorants in waterpipe tobacco and from the charcoal used to heat it. Additionally, a #ToxSpotlight article highlights how qualified kidney injury biomarkers demonstrate value during early clinical drug development while another #ToxSpotlight article identifies assessment criteria for in vitro studies.

• In-Depth Review: “Toxicity of Waterpipe Tobacco Smoking: The Role of Flavors, Sweeteners, Humectants, and Charcoal” (open access; topic category: in-depth review)
• ToxSpotlight Article: “Qualified Kidney Injury Biomarkers Demonstrate Value During Early Clinical Drug Development” (free to read; topic category: biomarkers)
• ToxSpotlight Article: “Identifying Assessment Criteria for In Vitro Studies: A Method and Item Bank” (open access; topic category: emerging technologies, methods, and models)

Other papers in the October 2024 issue (sorted by topic category) are:

Biomarkers

• “A Transcriptomic Biomarker Predictive of Cell Proliferation for Use in Adverse Outcome Pathway-Informed Testing and Assessment”

• “Identification of a Substrate of the Renal Tubular Transporters for Detecting Drug-Induced Early Acute Kidney Injury”

Developmental and Reproductive Toxicology

• “Corticosteroids Alter Kidney Development and Increase Glomerular Filtration Rate in Larval Zebrafish (Danio rerio)”

• “Quantitative Label-Free Proteomic Analysis of Mouse Ovarian Antral Follicles Following Oral Exposure to a Human-Relevant Mixture of Three Phthalates”

Neurotoxicology

• “Copper-Mediated Neurotoxicity and Genetic Vulnerability in the Background of Neurodegenerative Diseases in C. elegans”

• “Developmental Origins of Parkinson’s Disease Risk: Perinatal Exposure to the Organochlorine Pesticide Dieldrin Leads to Sex-Specific DNA Modifications in Critical Neurodevelopmental Pathways in the Mouse Midbrain”

• “Insights into Brominated Flame Retardant Neurotoxicity: Mechanisms of Hippocampal Neural Cell Death and Brain Region-Specific Transcriptomic Shifts in Mice”

• “Robust Differential Gene Expression Patterns in the Prefrontal Cortex of Male Mice Exposed to an Occupationally Relevant Dose of Laboratory-Generated Wildfire Smoke”

Organ Specific Toxicology

• “Assessing the Interplay Between Off-Target Promiscuity, Cytotoxicity, and Tolerability in Rodents to Improve the Safety Profile of Novel Anti-Malarial Plasmepsin X Inhibitors”

• “Deconvoluting and Derisking QRS Complex Widening to Improve Cardiac Safety Profile of Novel Plasmepsin X Antimalarials”

• “Formaldehyde and the Transient Receptor Potential Ankyrin-1 Contribute to Electronic Cigarette Aerosol-Induced Endothelial Dysfunction in Mice”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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