Blogs

The November 2024 issue of Toxicological Sciences includes a Contemporary Review that provides a summary of current scientific understanding on how medicinal Cannabis affects the thymus and its potential implications for disease treatment and immune health while a Research Brief examines how immune checkpoint blockade treatments may increase susceptibility to medication hypersensitivity by lowering the threshold for T-cell responses to drug antigens. Additionally, two #ToxSpotlight articles highlight Elucidation of γ-glutamyl-β-cyanoalanylglycine biosynthesis in mammalian cells by LC-QTOF-MS and show that HTTr can support chemical risk assessment by identifying in vitro points of departure, predicting chemicals’ mechanisms of action, and grouping chemicals with similar bioactivity profiles.

• Contemporary Review: “Exploring the Interplay Between Cannabinoids and Thymic Functions” (free to read; topic category: contemporary review)
• Research Brief: “Immune Checkpoint Blockade Lowers the Threshold of Naïve T-Cell Priming to Drug-Associated Antigens in a Dose-Dependent Fashion” (open access; topic category: research brief)
• ToxSpotlight Article: “Elucidation of C-Glutamyl-B-Cyanoalanylglycine Biosynthesis in Mammalian Cells by LC-QTOF-MS” (free to read; topic category: biomarkers)
• ToxSpotlight Article: “Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping” (free to read; topic category: molecular, biochemical, and systems toxicology)

Other papers in the November 2024 issue (sorted by topic category) are:

Biomarkers

“Wedelolactone Inhibits Ferroptosis and Alleviates Hyperoxia-Induced Acute Lung Injury via the Nrf2/HO-1 Signaling Pathway”

Developmental and Reproductive Toxicology

“Adolescent Exposure to a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) Depletes the Ovarian Reserve, Increases Ovarian Fibrosis, and Alters the Hippo Pathway in Adult Female Mice”

“Aryl Hydrocarbon Receptor-Dependent Toxicity by Retene Requires Metabolic Competence” (open access)

“Mixtures of Phthalates Disrupt Expression of Genes Related to Lipid Metabolism and Peroxisome”

Emerging Technologies, Methods, and Models

“Feature-Agnostic Metabolomics for Determining Effective Subcytotoxic Doses of Common Pesticides in Human Cells”

Genetic and Epigenetic Toxicology

“Assessment of In Vivo Chemical Mutagenesis by Long-Read Sequencing”

Neurotoxicology

“Demyelination and Impaired Oligodendrogenesis in the Corpus Callosum Following Lead Exposure”

Organ Specific Toxicology

“Associations Between Per- and Polyfluoroalkyl Substance Exposures and Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) in Adult National Health and Nutrition Examination Survey 2017 to 2018”

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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