Blogs

The December 2024 issue of Toxicological Sciences includes an Editoral that thanks the volunteer service of experts who conducted peer reviews for ToxSci in 2024. A Contemporary Review covers epidemiological, animal, and cell studies on PM2.5 exposure and bone health, as well as studies on PM2.5-induced diseases with skeletal complications, while an In-Depth Review centers on the evolution of RAS inhibitors in cancer therapy, delving into the common adverse effects associated with these inhibitors, their underlying mechanisms, and the potential strategies for mitigation. Additionally, two #ToxSpotlight articles are featured: One highlights a pharmacokinetic analysis of nicotine and its metabolites in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine while the other discusses the hemolytic toxicity tapestry of peptides using chemical space complex networks.

• Editorial: “Thank You, ToxSci 2024 Reviewers” (free to read; topic category: editorial)

• Contemporary Review: “Fine Particulate Matter and Osteoporosis: Evidence, Mechanisms, and Emerging Perspectives” (free to read; topic category: contemporary review)

• In-Depth Review: “Development and Safety of Investigational and Approved Drugs Targeting the RAS Function Regulation in RAS Mutant Cancers” (topic category: in-depth review)

• ToxSpotlight Article: “Pharmacokinetic Analysis of Nicotine and Its Metabolites (Cotinine and Trans-30-hydroxycotinine) in Male Sprague-Dawley Rats Following Nose-Only Inhalation, Oral Gavage, and Intravenous Infusion of Nicotine” (free to read; topic category: biomarkers)

• ToxSpotlight Article: “Unraveling the Hemolytic Toxicity Tapestry of Peptides Using Chemical Space Complex Networks” (free to read; topic category: molecular, biochemical, and systems toxicology)

Other papers in the December 2024 issue (sorted by topic category) are:

Biomarkers
“Effects Of Therapeutically Approved Individual Bile Acids on the Development of Metabolic Dysfunction-Associated Steatohepatitis a Low Bile Acid Mouse Model”

Carcinogenesis
“Urinary Bladder Carcinogenic Potential of 4,40-methylenebis(2-chloroaniline) in Humanized-Liver Mice”

Clinical and Translational Toxicology
“Schisandrin C Prevents Regorafenib-Induced Cardiotoxicity by Recovering EPHA2 Expression in Cardiomyocytes”

Endocrine Toxicology
“Profiling the Endocrine-Disrupting Properties of Triazines, Triazoles, and Short-Chain PFAS” (open access)

Environmental Toxicology
“Oral Exposure to Benzalkonium Chlorides in Male and Female Mice Reveals Alteration of the Gut Microbiome and Bile Acid Profile”

Genetic and Epigenetic Toxicology
“Comprehensive Genotoxicity and Carcinogenicity Assessment of Molnupiravir” (open access)

Mixtures Toxicology
“Effects of Mixed Metal Exposure on MRI Metrics in Basal Ganglia”

Molecular, Biochemical, and Systems Toxicology
“The Herbicide Acetochlor Causes Lipid Peroxidation by Inhibition of Glutathione Peroxidase Activity”

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