Blogs

The January 2025 issue of Toxicological Sciences includes a Contemporary Review that presents findings on the capture and inactivation of electrophiles by intracellular glutathione, reactive sulfur species, and extracellular cysteine while an In-Depth Review outlines mechanistic investigations into tolvaptan and associated idiosyncratic drug-induced liver injury events. A Forum article covers potential next steps for sponsors to reduce animal use in drug development while a Research Brief highlights the limitation of using acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. Additionally, two #ToxSpotlight articles are featured: One highlights the development of machine learning–based quantitative structure–activity relationship models for predicting plasma half-lives of drugs in six common food animal species while the other reports human serum albumin affinities for 65 structurally diverse PFAS from 20 chemical classes.

Other papers in the January 2025 issue (sorted by topic category) are:

Carcinogenesis
“MAD2L1 Supports MYC-Driven Liver Carcinogenesis in Mice and Predicts Poor Prognosis in Human Hepatocarcinoma”

Emerging Technologies, Methods, and Models
“Physiological Liver Microtissue 384-Well Microplate System for Preclinical Hepatotoxicity Assessment of Therapeutic Small Molecule Drugs” (open access)