The February 2025 issue of Toxicological Sciences includes a Contemporary Review that provides insights on the impact of common neonicotinoid pesticides on male and female reproductive health in mammals, while an In-Depth Review summarizes the current state of the science regarding the study design and bioinformatics workflows for tPOD derivation. A Forum article covers the European regulatory framework on chemicals. Additionally, two #ToxSpotlight articles are featured: One captures constructive considerations from practitioners in the field that can increase the utility of epidemiologic studies in chemical risk assessment and harmonize the approach for use in dose-response assessment that will ultimately reduce uncertainty related to chemical exposures, while the other investigated the concentration of toxic metals in the soil of a major cement factory and nearby groundwater.