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A new ToxPoint article argues that “Copper Is the New Showstopper,” while a commentary calls for patient-relevant tissue models in the September 2022 issue of Toxicological Sciences (ToxSci), the official journal of the Society of Toxicology (SOT). Other featured articles include a contemporary review on machine learning and artificial intelligence, research on inflammatory cell responses in protein-c mutant lungs to ozone exposure, and a study that explores whether nonanimal systematic safety assessments can be used for safety decisions associated with human health. The issue also has an “In Memoriam” tribute to Donald J. Reed, who was SOT President for the 1991–1992 leadership year.

Here are the science highlights from ToxSci Volume 189, Issue #1:

• “ToxPoint: Copper Is the New Showstopper” (Open Access)
• Commentary “New Drug Modalities Demand a Refined Preclinical Safety Assessment: A Call for Patient-Relevant Tissue Models”
• Contemporary Review “Machine Learning and Artificial Intelligence in Toxicological Sciences” (free to read for nonsubscribers)
• ToxSpotlight Article “Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung (free to read for nonsubscribers)
• ToxSpotlight Article “Are Nonanimal Systemic Safety Assessments Protective? A Toolbox and Workflow” (Open Access)

The September 2022 issue of ToxSci, as well as all past issues, are available on the ToxSci website.

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

ToxSci: Your science. Your journal.

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