Blogs

In the February 2023 issue of Toxicological Sciences, a Contemporary Review examines manganese-induced neuronal apoptosis. The issue also includes ToxSpotlight articles on how cryopreserved human precision-cut lung slices can be a relevant model for use in regulatory applications and how lipid dysregulation may be associated with progression of silica-induced pulmonary fibrosis.

• Contemporary Review: “Manganese-Induced Neuronal Apoptosis: New Insights into the Role of Endoplasmic Reticulum Stress in Regulating Autophagy-Related Proteins” (free to read)
• ToxSpotlight Article: “Cryopreserved Human Precision-Cut Lung Slices Provide an Immune Competent Pulmonary Test System for ‘On-Demand’ Use and Long-Term Cultures” (Open Access; topic category: emerging technologies, methods, and models)
• ToxSpotlight Article: “Lipid Dysregulation Associated with Progression of Silica-Induced Pulmonary Fibrosis” (free to read; topic category: environmental toxicology)

Other papers in the February 2023 issue (sorted by topic category) are:

Biomarkers

• “Bone Morphogenetic Protein 4 Is involved in Cadmium-Associated Bone Damage” (Open Access)

Computational Toxicology and Databases

• “Incorporation of Rapid Association/Dissociation Processes in Tissues into the Monkey and Human Physiologically Based Pharmacokinetic Models for Manganese” (Open Access)

Developmental and Reproductive Toxicology

• “Cannabidiol-Induced Transcriptomic Changes and Cellular Senescence in Human Sertoli Cells”
• “Maternal Exposure to Perfluorobutane Sulfonate (PFBS) during Pregnancy: Evidence of Adverse Maternal and Fetoplacental Effects in New Zealand White (NZW) Rabbits”

Endocrine Toxicology

• “In Vitro Transcriptomic Analyses Reveal Pathway Perturbations, Estrogenic Activities, and Potencies of Data-Poor BPA Alternative Chemicals” (Open Access)

Environmental Toxicology

• “2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Liver Lipid Metabolism Disorder via the ROS/AMPK/CD36 Signaling Pathway”
• “Cellular and Molecular Responses to Ethyl-Parathion in Undifferentiated SH-SY5Y Cells Provide Neurotoxicity Pathway Indicators for Organophosphorus Impacts” (Open Access)

Immunotoxicology

• “Myricetin Treatment Has Ameliorative Effects in DNFB-Induced Atopic Dermatitis Mice under High-Fat Conditions”

Molecular, Biochemical, and Systems Toxicology

• “Increased Sensitivity to Chemically Induced Colitis in Mice Harboring a DNA-Binding Deficient Aryl Hydrocarbon Receptor” (Open Access)
• “Lnc-HZ03 Promotes TRBP-Mediated Splicing of Pre-miR-hz03 to Generate miR-hz03 in Human Trophoblast Cells”
• “Structure-Activity Relationship Read-Across and Transcriptomics for Branched Carboxylic Acids”

Neurotoxicology

• “Maternal Organophosphate Flame Retardant Exposure Alters the Developing Mesencephalic Dopamine System in Fetal Rat”
• “Reproductive and Developmental Toxicity following Exposure to Organophosphate Ester Flame Retardants and Plasticizers, Triphenyl Phosphate and Isopropylated Phenyl Phosphate, in Sprague Dawley Rats”

Organ-Specific Toxicology

• “Myclobutanil-Mediated Alteration of Liver-Gut FXR Signaling in Mice”
• “Selective Inhibition of Integrin αvβ6 Leads to Rapid Induction of Urinary Bladder Tumors in Cynomolgus Macaques” (Open Access)

ToxSci Volume 191, Issue #2, as well as all past issues, is available on the ToxSci website.

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time.

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