Blogs

The March 2023 issue of Toxicological Sciences includes an editorial on the 2021–2022 ToxSci Paper of the Year recipient and honorable mention and ToxSpotlight articles on how arsenic causes distinct gene expression changes in macrophages polarized in vitro with either interferon-γ or interleukin-4 and how aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice. The issue also features in-depth reviews of the connection between air pollution and respiratory infections and of the mode of action for the development of liver lesions in mice after oral exposure to ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate (HFPO-DA).

• Editorial: “2021–2022 Toxicological Sciences Paper of the Year” (free to read)
• In-Depth Review: “Air Pollution and Respiratory Infections: The Past, Present, and Future” (free to read)
• In-Depth Review: “Assessment of the Mode of Action Underlying Development of Liver Lesions in Mice following Oral Exposure to HFPO-DA and Relevance to Humans” (Open Access)
• ToxSpotlight Article: “Arsenic Causes Distinct Gene Expression Changes in Macrophages Polarized In Vitro with Either Interferon-γ or Interleukin-4” (free to read; topic category: immunotoxicology)
• ToxSpotlight Article: “Aryl Hydrocarbon Receptor Activation Affects Nitrergic Neuronal Survival and Delays Intestinal Motility in Mice” (free to read; topic category: neurotoxicology)

Other papers in the March 2023 issue (sorted by topic category) are:

Carcinogenesis

• “Cigarette Smoke and Tumor Microenvironment Copromote Aggressiveness of Human Breast Cancer Cells”

Endocrine Toxicology

• “The Role of Small GTPases in Bisphenol AF-Induced Multinucleation in Comparison with Dibutyl Phthalate in the Male Germ Cells”

Environmental Toxicology

• “Considering Developmental Neurotoxicity In Vitro Data for Human Health Risk Assessment Using Physiologically-Based Kinetic Modeling: Deltamethrin Case Study” (Open Access)

Genetic and Epigenetic Toxicology

• “Circ_0089282 Inhibits Carbon Black Nanoparticle-Induced DNA Damage by Promoting DNA Repair Protein in the Lung”

Immunotoxicology

• “Next-Generation PFAS 6:2 Fluorotelomer Sulfonate Reduces Plaque Formation in Exposed White-Footed Mice”
• “Identification of Flucloxacillin-Modified Hepatocellular Proteins: Implications in Flucloxacillin-Induced Liver Injury”

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