The August 2013, Vol. 134, Issue 2 of
Toxicological Sciences is now available
online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in
Toxicological Sciences as soon as they are accepted and posted to the website, register
online.The paper chosen for the Editor's Highlight in this issue is
Environmental Toxin–Linked Nonalcoholic Steatohepatitis and Hepatic Metabolic Reprogramming in Obese Mice by
Ratanesh Kumar Seth, Ashutosh Kumar, Suvarthi Das, Maria B. Kadiiska, Gregory Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. The Editor's Highlight prepared by Intermin Editor-in-Chief Matthew Campen states that "
Seth and colleagues examined a two-hit model for nonalcoholic steatohepatitis, showing that bromodichloromethane interacts with a high fat diet to induce liver inflammation and metabolic alterations in a CYP2E1-dependent manner. Moreover, bromodichloromethane dramatically affected the satiety-inducing leptin pathway, which appears to be mechanistically involved in the metabolic pathogenesis. In addition to characterizing the phenomenon, this study highlights the potential that genetic polymorphisms and diet may play in determining susceptibility to the metabolicoutcomes of common environmental contaminants. The overall metabolic disturbances are likely to be more complex and systemic than described in the present article and future research in this area will be exceedingly valuable to understanding the impact of environmental contaminants on public health." Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology.