A March 24, Symposium, Local and Systemic Toxicity from Cobalt and Chromium-Containing Hip Prostheses, addressed current research findings related to the potential health effects of metal-on-metal prosthesis. Movement of loosened components in a failing prosthesis and friction between bearing surfaces can result in increased local and systemic concentrations principally of cobalt and chromium. These effects vary with the metal, its concentration, physical form, and valency. Chaired by Allistar Vale, School of Biosciences and College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, and Jeffrey Brent, School of Medicine, University of Colorado, Aurora, Colorado, this session addressed new research findings for which there is growing evidence of concern.
Now there are over 500,000 patients in the United States who have received a metal-on-metal hip prosthesis. Since 2009, a small, but growing number, of patients with systemic toxicity in association with metal-containing hips have been reported. Clinical studies have demonstrated that cobalt can cause cardiovascular, visual, auditory, and thyroid dysfunction. These effects are more frequently seen in susceptible groups, ranging from individuals with other health issues to malnourished heavy drinkers. Additional data is needed to advance understanding of this public health issue.
Moreover, this symposium provided a forum for discussing a topic related to the SOT Annual Meeting theme of Advancing Clinical and Translational Toxicology. Other presenters included Mark Wilkinson, Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom; Sally Bradberry, West Midlands Poisons Unit, City Hospital, Birmingham, United Kingdom; and Michael Kosnett, School of Medicine, University of Colorado, Aurora, Colorado.