John J. Lemasters will deliver the Distinguished Toxicology Scholar Award Lecture, "Mitochondria: Crossroads of Cell Survival, Death, and Transformation," Wednesday, March 13, 12:30 pm–1:20 pm, Grand Ballroom C2. Dr. LeMasters is a professor and director, Center for Cell Death, Injury and Regeneration, Department of Biochemistry & Molecular Biology and Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina. Dr. Lemaster's research interests concern the cellular and molecular mechanisms underlying toxic, hypoxic, and ischemia/reperfusion injury. His laboratory applies new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, chelatable iron, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability, and other biochemical parameters during the pathogenesis of lethal cell injury. These approaches are being extended to true in vivo (intravital) imaging of cells and tissues in living animals. In addition to researching cellular and molecular mechanisms of apoptosis and necrosis, Dr. LeMasters also is concerned with organ preservation for transplantation surgery; mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy, and calcium homeostasis; oxidative stress; ischemia/repurfusion; and confocal and multiphoton microscopy of living cells.