Lois D. Lehman-McKeeman and Norbert E. Kaminski (currently SOT President and Vice President) recently authored an editorial in Toxicological Sciences (ToxSci ) titled “The Hazards of Playing it Safe: Perspectives on How the Society of Toxicology Should Contribute to Discussions on Timely Issues of Human and Environmental Safety.” The article is intended to be a call to action that encourages our membership to speak out on relevant toxicology issues and to challenge the Society to respond more regularly and vigorously on matters where toxicology needs to have a voice. Drs. Lehman-McKeeman and Kaminski address the need for the Society to contribute to ongoing scientific debate and discussions to ensure that sound science is used in all matters of safety evaluation and regulation.The Society’s mission to create a safer and healthier world dictates that as experts in hazard identification and risk assessment, we need to contribute to advancing the recognition of how our science can and should be used. The Editorial is currently available in the Advanced Access section of ToxSci.