The May 2018, Vol. 163, Issue 1 of Toxicological Sciences includes many articles that will be of interest and importance to you, including a Historical Perspective and a Contemporary Review on the zebrafish research model.
As you look inside ToxSci, please take note of the remarks by ToxSci Editor-in-Chief Gary W. Miller on the challenges to reproducibility presented by informatics approaches:
“Confirming deletion of a gene product by a simple western blot has a comforting feel. Statistics are not needed to demonstrate the significance of the result. Yet most of science is not so simple. As we use more -omic scale approaches, we rely more heavily on statistical tools, data visualization, and algorithms to interpret the results. We load our data into a seemingly black box and wait for the results of months of work to be delivered. I have written about the challenges of reproducibility in basic laboratory and animals studies, but informatics approaches represent an even more daunting task. I offer no solutions here, except to remind investigators to learn more about the underlying processes, code, and algorithms to which we subject our data and to consider alternative tools to see if similar results are found. In the meantime, I encourage you to look inside ToxSci for the most influential research in the field of toxicology.”
Also in this most recent ToxSci issue, you will find four Editor's Highlights prepared by ToxSci Associate Editors Aaron B. Bowman on Microelectrode Arrays and Seizures, William H. Farland on In Vitro-In Vivo Extrapolation Toxicokinetics, Jeffrey Peters on Paradoxical Effects of Perflourooctanic Acid in Humans, and Matthew J. Campen on Dietary Intervention for Pulmonary Injury.