Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, will deliver the Keynote Medical Research Council (MRC) Lecture, “Role of microRNAs in Control of Gene Expression in Human Physiology and Pathology,” on Tuesday, March 13, 8:00 am–9:00 am, Moscone Convention Center, Room 103. This lecture will provide current knowledge about the mechanism of miRNA-mediated repression of gene expression, procedures to identify miRNA targets, as well as a role of miRNAs in selected human pathologies and the use of miRNA profiling as a diagnostic tool in human diseases and in tissue and cell injuries. MiRNAs have been found to be secreted from cells via exosomes and their profiling in human serum and other body fluids appears to be a promising diagnostic tool in different pathologies. MiRNAs also may play important roles in cellular responses to xenobiotic stresses and in control of drug-metabolizing enzymes. In addition, miRNAs or compounds blocking their function represent promising therapeutic agents. For more information about the featured sessions at the SOT 2012 Annual Meeting, visit the SOT Website.