The June 2014 Vol. 139, Issue 2 of Toxicological Sciences is now available online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in Toxicological Sciences as soon as they are accepted and posted to the website, please register online.
The Forum article in this issue is The Role of Toxicological Science in Meeting the Challenges and Opportunities of Hydraulic Facturing by Bernard D. Goldstein, Bryan W. Brooks, Steven D. Cohen, Alexander E. Gates, Michael E. Honeycutt, John B. Morris, Jennifer Orme–Zavaleta, Trevor M.Penning, and John Snawders. An Executive Summary of this article serves as an Issue Statement for the Society of Toxicology (SOT) on Hydraulic Fracturing. As part of the Society’s mission to build for the future of toxicology and to promote the recognition of Toxicology by increasing the reliance of policy, regulatory, and corporate decision-makers on the science of Toxicology, SOT has developed a procedure for writing Issue Statements.
The paper selected for the Editor's Highlight in this issue is Prenatal Arsenic Exposure and Shifts in the Newborn Proteome: Interindividual Differences in Tumor Necrosis Factor (TNT)–Responsive Signaling by Kathryn A. Bailey, Jessica Laine, Julia E. Rager, Elizabeth Sebastian, Andrew Olshan, Lisa Smeester, Zuzana Drobná, Miroslav Stýblo, Marisela Rubio-Andrade, Gonzalo García-Vargas, and Rebecca C. Fry. The Editor's Highlight by Editor–in–Chief Gary W. Miller and Associate Editor Ronald N. Hines states that " Babies, infants and young children are not just small adults; their physiology and biochemistry differs in countless ways creating a need for research on this vulnerable population. But such research poses numerous ethical and moral challenges. The acquisition of umbilical cord blood provides an opportunity to assess the newborn's environment without risk to the child. In this issue of the Journal, Bailey and coworkers used antibody arrays to examine protein profiles in umbilical cord blood and compared it to levels of arsenic in the mothers' urine and drinking water. The study population was based in G'omez Palacio, Mexico, where arsenic levels are well above regulatory guidelines. Protein network analysis revealed several proteins involved in tumor necrosis factor signaling were elevated in the offspring of highly exposed mothers, suggesting that elevated arsenic induces widespread inflammatory signaling. Such markers could ultimately be used to assess the impact of arsenic exposure in this and other vulnerable populations and may lead to mechanisms whereby arsenic exposure in utero contributes to adverse outcomes later in life."
The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish the most influential research in the the field of toxicology.