The November 2013, Vol. 136, Issue 1 of
Toxicological Sciences is now available
online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in
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online."Improvements in human health risk assessment are necessary to reduce uncertainty and move toward a more quantitative estimate of risk. Several endeavors are making such improvements. The shift to include more detailed descriptions of the qualitative events underlying an adverse health outcome and the dose response evaluation of those events has necessitated a standardized manner in which the production of an adverse health outcome is characterized. Among the valuable recent advances is the Adverse Outcome Pathway. The AOP is a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse health outcome at a biological level of organization relevant to risk assessment. Having developed this level of understanding, the human relevance of a mode of action or AOP can be ascertained. Given the differential distribution of bile salt export mechanisms between rodents and humans, the development of an AOP for bile salt export should aid the health risk assessments based on cholestatic liver injury. The developed AOP includes multiple specific mechanisms that may be interlinked within the AOP, thus indicating the value of developing an AOP for the sake of mixtures risk assessment, wherein chemicals are grouped according to similarities or independence in their modes of action. This manuscript presents the AOP for cholestatic liver injury initiated by bile salt export inhibition."
Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology.