The January 2013, Vol. 131, No. 1 issue of
Toxicological Sciences is now available
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The paper chosen for the Editor's Highlight in this issue is as folllows:
Novel Assays for Detection of Urinary KIM-1 in Mouse Models of Kidney Injury by
Venkata S. Sabbisetti, Kazumi Ito, Chang Wang, Li Yang, Stephen C. Mefferd, and Joseph V. Bonventre. ToxSci Editor-in-Chief Michael L. Cunningham notes in his Editor's Highlight that "Sensitive and early noninvasive biomarkers of renal toxicity are needed to augment or replace current biomarkers. This report describes the development and validation of two bioassays for mouse urinary KIM-1 that may be of clinical value. Using a microbead-based assay and a quantitative dipstick assay, these assays demonstrated sensitivity and stability for detection of KIM-1 in models of renal toxicity when other biomarkers remained unchanged."Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology with an impact factor of 4.652.