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ToxSci February 2013 Vol. 131, No. 2 Now Online

By Marcia Lawson posted 01-29-2013 08:25 AM

  
The February  2013, Vol. 131, No. 2 issue of Toxicological Sciences is now available online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in Toxicological Sciences as soon as they are accepted and posted to the website, register online.
The paper chosen for the Editor's Highlight in this issue is A Species Difference in the Peroxisome Proliferator-Activated Receptor α-Dependent Response to the Developmental Effects of Perfluorooctanoic Acids by Prajakta P. Albrecht, Nicole E. Torsell, Prasad Krishnan, David J. Ehresman, Steven R. Frame, Shu-Ching Chang, John L. Butenhoff, Gerald L. Kennedy, Frank J. Gonzalez, and Jeffrey M. Peters.
ToxSci Editor-in-Chief Michael L. Cunningham notes in his Editor's Highlight that "Species-specific toxicity of chemicals is usually demonstrated in adult animal models. These authors demonstrated the species-specific toxicity of the peroxisome proliferator perfluorooctanoic acid (PFOA) in a developing mouse model. Using wild-type, PPARα-null and PPARα—humanized mice, the authors demonstrated that the developmental/postnatal effects of PFOA are differentially mediated by mouse compared to human PPARα."
Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology with an impact factor of 4.652.
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