The December 2012, Vol. 130, No. 2 issue of Toxicological Sciences is now available online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in Toxicological Sciences as soon as they are accepted and posted to the website, register online.
The paper chosen for the Editor's Highlight in this issue is "A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase" by Wendy J. Bailey, Dan Holder, Hima Patel, Pam Devlin, Raymond J. Gonzalez, Valerie Hamilton, Nagaraja Muniappa, Diane M. Hamlin, Craig E. Thomas, Frank D. Sistare, and Warren E. Glaab.
ToxSci Editor-in-Chief Michael L. Cunningham notes in his Editor's Highlight that "Detection of hepatobiliary toxicity by traditional serum biomarkers alanine aminotransferase (ALT) and aspartate aminotransferase (AST) lack sensitivity and specificity and do not detect biliary injury well. The current study evaluated the novel biomarkers alpha-glutathione S-transferase (GSTA), arginase 1 (ARG1), and 4-hydroxyphenylpyruvate dioxygenase (HPD) across 34 acute toxicity rat studies. They concluded that these biomarkers were more sensitive at detecting single cell necrosis in rat liver and were able to detect biliary injury better than by using existing biomarkers. These novel biomarkers may be useful in the clinical detection of liver and biliary damage in humans."
Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology with an impact factor of 4.652.