The July 2013, Vol. 134, Issue 1 of
Toxicological Sciences is now available
online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in
Toxicological Sciences as soon as they are accepted and posted to the website, register
online.The paper chosen for the Editor's Highlight in this issue is
Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment by
Russell S. Thomas, Scott C. Wesselkamper, Nina Ching Y. Wang, Q. Jay Zhao, Dan D. Petersen, Jason C. Lambert, Ila Cote, Longlong Yang, Eric Healy, Michael B. Black, Harvey J. Clewell III, Bruce C. Allen, and Melvin E. Andersen.The Editor's Highlight prepared by
Toxciological Sciences Associate Editor Jeffrey Fisher states that: "In this manuscript, a temporal comparison between
in vivo gene expression and histologic markers of toxicity demonstrates significant concordance. These results shed light on which gene changes may be the most important for targeted
in vivo analysis and additional consideration in risk assessment. The advancement of high-throughput
in vivo assays to assess genetic changes may represent significant resource saving opportunities for toxicologists when
in vivo findings corroborate the involvement of specific genes in a toxicity pathway. Studies such as this provide assurance that relying on
in vivo data describing gene changes has an important role in health risk assessment."