The December 2013, Vol. 136, Issue 2 of Toxicological Sciences is now available online. To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in Toxicological Sciences as soon as they are accepted and posted to the website, please register online.
The paper chosen for the Editor's Choice in this issue is Endocrine Disruptors Differentially Target ATP-Binding Cassette Transporters in the Blood-Testis Barrier and Affect Leydig Cell Testosterone Secretion In Vitro by Anita C. A. Dankers, Maarke J. E. Roelofs, Aldert H. Piersma, Fred C. G. J. Sweep, Frans G. M. Russel, Martin van den Berg, Majorie B. M. van Duursen, and Rosalinde Masereeuw. In the Editor's High, the Editor–in–Chief of Toxicoloigical Sciences Gary Miller stated that: "Over the past several decades, there has been an increase in male infertility, and there is evidence that this may be due to exposure to environmental contaminants. The blood testis barrier represents a key line of defense for the delicate processes of spermatogenesis and steroid production. The barrier contains several transporters that regulate the movement of chemicals. In this paper, the authors report that the ATP-binding cassette transporters, including those that are responsible for transporting testosterone precursors (P-glycoprotein), may be a target of suspected endocrine disrupting chemicals, such as tetrabromobisphenol A. These findings suggest that evaluation of endocrine disrupting chemicals should consider effects on the blood testis barrier transporters."
Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology.