The June 2013, Vol. 133, No. 2 issue of
Toxicological Sciences is now available
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The paper chosen for the Editor's Highlight in this issue is
Hydroxyurea Exposure Triggers Tissue-Specific Activation of p38 Mitogen-Activated Protein Kinase Signaling and the DNA Damage Response in Organogenesis-Stage Mouse Embryos by Serena Banh and Barbara F. Hales. Co-Interim Editor-in-Chief Matthew Campen notes in the Editor's Highlight that "Hydroxyurea, a commonly used antineoplastic agent, induces teratogenesis accompanied by oxidative stress in rodent models. Banh and Hales report on the early and transient activation of p38 MAPK downstream of MEK3/6 following in utero exposure of murine embryos to hydroxyurea at gestational day 9. Hydroxyurea had a primary impact on neurological structures, where nuclear translocation of phospho-p38 and formation of γH2AX foci, accompanied by an increase in pyknotic nuclei, were observed in the malformation-sensitive caudal neuroepithelium. In contrast, the heart appeared protected despite the accumulation of γH2AX foci, the nuclear expression of phospho-p38 MAPK and the development of pyknotic nuclei were minimal in cardiac regions, suggesting that hydroxyurea may induce tissue-specific DNA repair mechanisms, such as nucleotide excision or crosslink repair." John C. Lipscomb also is serving as the Co-Interim Editor-in-Chief of
Toxicological Sciences.
Toxicological Sciences, the official journal of SOT, is among the most highly cited original research journals in Toxicology with an impact factor of 4.652.