|
Emanuela Corsini is a tenured full professor in toxicology at the School of Pharmacy at the Università degli Studi di Milano, Milan, Italy. As such, she organizes and teaches courses in the field of Toxicology at the School of Pharmacy and the School of Environmental Sciences, University of Milan. She is the Chair of the Master degree in Safety Assessment of Xenobiotics and Biotechnological Products at the University of Milan. She has been active in training undergraduate and graduate students at her own university and has also developed and presented lectures for other academic institutions and professional societies, as well as for several SOT CE courses. Since 2013, she is professor at the Master in Cosmetic Science and Technology, University of Siena, and at the Master in Cosmetological Sciences, University of Pavia, holding courses on Cosmetic safety evaluation. She has also served as lecturer at the Course Safety Assessment of Cosmetics in the EU, organized by the Vrije Universiteit Brussel.
Her research focuses on the refinement of alternative in vitro tests for immunotoxicity, promoting the regulatory acceptance of alternative methods, and on the understanding the mechanism of action of immunotoxic/immunomodulatory compounds at the molecular level.
Dr. Corsini has served on multiple EURL-ECVAM, JaCVAM, ICCVAM and OECD Panels and working groups to establish scientific confidence in alternative methods in immunotoxicology testing, performance standards for these novel assays and the development of integrated testing strategies for their use as part of comprehensive and predictive assessments. She has authored over 190 research publications in toxicology and related disciplines in peer-reviewed journals.
She is active in numerous scientific and professional organizations and serves on several editorial boards of toxicology journals. Dr. Corsini currently serves as Secretary General of IUTOX (2019-2025). From 1999-2005 she served as the Treasurer for the Association for In Vitro Toxicology; from 2009-2013 she was a Member of the EUROTOX Education Sub Committee; from 2005-2011 she was the Chair of the Immunotoxicology and Chemical Specialty Section at EUROTOX; from 2010-2016 she was a member of the IUTOX Executive Committee; from 2013-2021 she has been a member of the EUROTOX Executive Committee.
SOT—Elected Positions:
Memberships, Chairs, and/or Offices held in SOT Appointed Committees, Regional Chapter, Special Interest Group, Specialty Section Positions, and SOT Awards: Dermal Toxicology Specialty Section 2007–2014; Immunotoxicology Specialty Section 2000–present; Immunotoxicology Specialty Section Vice President-Elect 2017–2018, Vice President 2018-2019, President 2019-2020, Past President/Councilor 2020-2021; ICTXV Program Committee 2017–2019; SOT Awards Committee 2017-2019; Global Collaboration Coffee and Initiatives 2014–2016, 2019-present; Board of Publications Award 1995; Immunotoxicology Specialty Section Outstanding Young Investigator Award 2008; Immunotoxicology Specialty Section Vos Award 2021.
ORCID ID: 0000-0002-6927-5956
Bibliometric parameters:
Google scholar
Citations 10691
h-index: 55
Publications in the last 5 years:
Germolec DR, Lebrec H, Anderson SE, Burleson GR, Cardenas A, Corsini E, Elmore SE, Kaplan BLF, Lawrence BP, Lehmann GM, Maier CC, McHale CM, Myers LP, Pallardy M, Rooney AA, Zeise L, Zhang L, Smith MT. Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification. Environ Health Perspect. 2022 Oct;130(10):105001. doi: 10.1289/EHP10800
Masi M, Maddalon A, Iulini M, Linciano P, Galbiati V, Marinovich M, Racchi M, Corsini E, Buoso E. Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation. Toxicology. 2022 Oct;480:153321. doi: 10.1016/j.tox.2022.153321.
Maddalon A, Masi M, Iulini M, Linciano P, Galbiati V, Marinovich M, Racchi M, Buoso E, Corsini E. Effects of endocrine active contaminating pesticides on RACK1 expression and immunological consequences in THP-1 cells. Environ Toxicol Pharmacol. 2022 Oct;95:103971. doi: 10.1016/j.etap.2022.103971.
Pappalardo F, Russo G, Corsini E, Paini A, Worth A. Translatability and transferability of in silico models: Context of use switching to predict the effects of environmental chemicals on the immune system. Comput Struct Biotechnol J. 2022 Mar 26;20:1764-1777. doi: 10.1016/j.csbj.2022.03.024.
Iulini M, Maddalon A, Galbiati V, Corsini E. The Modified THP-1 Activation Assay for the In Vitro Identification of Drug-Inducing Systemic Hypersensitivity. Front Toxicol. 2022 Mar 3;4:814050. doi: 10.3389/ftox.2022.814050.
Maddalon A, Iulini M, Galbiati V, Colosio C, Mandić-Rajčević S, Corsini E. Direct Effects of Glyphosate on In Vitro T Helper Cell Differentiation and Cytokine Production. Front Immunol. 2022 Mar 10;13:854837. doi: 10.3389/fimmu.2022.854837.
Masi M, Racchi M, Travelli C, Corsini E, Buoso E. Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers. Cells. 2021 Nov 3;10(11):2999. doi: 10.3390/cells10112999
Maddalon A, Galbiati V, Colosio C, Mandić-Rajčević S, Corsini E. Glyphosate-based herbicides: Evidence of immune-endocrine alteration Toxicology. 2021 Jul;459:152851. doi: 10.1016/j.tox.2021.152851.
Brivio P, Buoso E, Masi M, Gallo MT, Gruca P, Lason M, Litwa E, Papp M, Fumagalli F, Racchi M, Corsini E, Calabrese F. The coupling of RACK1 with the beta isoform of the glucocorticoid receptor promotes resilience to chronic stress exposure. Neurobiol Stress. 2021 Jul 26;15:100372. doi: 10.1016/j.ynstr.2021.100372.
EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wölfle D, Corsini E, Cubadda F, De Groot D, FitzGerald R, Gunnare S, Gutleb AC, Mast J, Mortensen A, Oomen A, Piersma A, Plichta V, Ulbrich B, Van Loveren H, Benford D, Bignami M, Bolognesi C, Crebelli R, Dusinska M, Marcon F, Nielsen E, Schlatter J, Vleminckx C, Barmaz S, Carfí M, Civitella C, Giarola A, Rincon AM, Serafimova R, Smeraldi C, Tarazona J, Tard A, Wright M. Safety assessment of titanium dioxide (E171) as a food additive. EFSA J. 2021 May 6;19(5):e06585. doi: 10.2903/j.efsa.2021.6585.
Buoso E, Kenda M, Masi M, Linciano P, Galbiati V, Racchi M, Dolenc MS, Corsini E. Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells. Front Pharmacol. 2021 Sep 21;12:743991. doi: 10.3389/fphar.2021.743991
Corsini E, Buoso E, Galbiati V, Racchi M. Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity. Adv Exp Med Biol. 2021;1275:151-163. doi: 10.1007/978-3-030-49844-3_6
Nozza E, Valentini S, Melzi G, Vecchi R, Corsini E. Advances on the immunotoxicity of outdoor particulate matter: A focus on physical and chemical properties and respiratory defence mechanisms. Sci Total Environ. 2021 Mar 12;780:146391. doi: 10.1016/j.scitotenv.2021.146391.
Masi M, Garattini E, Bolis M, Di Marino D, Maraccani L, Morelli E, Grolla AA, Fagiani F, Corsini E, Travelli C, Govoni S, Racchi M, Buoso E. OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression. Oncogenesis. 2020 Dec 11;9(12):105. doi: 10.1038/s41389-020-00291-x.
Buoso E, Masi M, Racchi M, Corsini E. Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1. Int J Mol Sci. 2020 Dec 3;21(23):9229. doi: 10.3390/ijms21239229.
Galbiati V, Corsini E. Human keratinocytes and monocytes co-culture cell system: an important contribution for the study of moderate and weak sensitizers. Toxicol In Vitro. 2020 Jul 3;68:104929. doi: 10.1016/j.tiv.2020.104929.
Lanni C, Catanzaro M, Fagiani F, Racchi M, Corsini E, Govoni S. Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2. Signal Transduct Target Ther. 2020 May 29;5(1):84. doi: 10.1038/s41392-020-0191-1.
Corsini E, Facchetti G, Espositi S, Maddalon A, Rimoldi I, Christodoulou MS. Antiproliferative effects of chalcones in T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ. Arch Pharm (Weinheim). 2020 May 12:e2000062. doi: 10.1002/ardp.202000062.
Anlar HG, Galbiati V, Corsini E, BaŞaran N. Evaluation of the Possible Role of miRNAs in Chemical Allergen Potency. Turk J Pharm Sci. 2020 Aug;17(4):452-456. doi: 10.4274/tjps.galenos.2019.25349.
Buoso E, Masi M, Galbiati V, Maddalon A, M, Kenda M, Sollner Dolenc M, Marinovich M, Racchi M, Corsini E. Effect of estrogenic active compounds on the expression of rack1 and immunological implications. Arch Toxicol. 2020 Jun;94(6):2081-2095. doi: 10.1007/s00204-020-02756-9.
Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C, Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M, Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D, Inoue T, Roggen EL, Kojima H, Aiba S. An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals. Toxicol In Vitro. 2020 Aug;66:104832. doi: 10.1016/j.tiv.2020.104832.
Guzelj S, Gobec M, Urbančič D, Mlinarič-Raščan I, Corsini E, Jakopin Ž. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020 Mar 15;190:112089. doi: 10.1016/j.ejmech.2020.112089.
Galbiati V, Marinovich M, Corsini E. Mechanistic understanding of dendritic cell activation in skin sensitization: additional evidences to support potency classification. Toxicol Lett. 2020 Apr 1;322:50-57. doi: 10.1016/j.toxlet.2020.01.014.
Galbiati V, Cornaghi L, Papale A, Donetti E, Marinovich M, Corsini E. Study on the inflammasome nlrp3 and blimp-1/nlrp12 after keratinocyte exposure to contact allergens. Toxicol Lett. 2019 Jul 2;313:130-136. doi: 10.1016/j.toxlet.2019.07.003.
Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C. Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea. Molecules. 2018 Oct 26;23(11). pii: E2778. doi: 10.3390/molecules23112778.
Corsini E, Engin AB, Neagu M, Galbiati V, Nikitovic D, Tzanakakis G, Tsatsakis AM. Chemical-induced contact allergy: from mechanistic understanding to risk prevention. Arch Toxicol. 2018 Oct;92(10):3031-3050. doi: 10.1007/s00204-018-2283-z.
Villeneuve DL, Landesmann B, Allavena P, Ashley N, Bal-Price A, Corsini E, Halappanavar S, Hussell T, Laskin D, Lawrence T, Nikolic-Paterson D, Pallardy M, Paini A, Pieters R, Roth R, Tschudi-Monnet F. Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways. Toxicol Sci. 2018 Jun 1;163(2):346-352. doi: 10.1093/toxsci/kfy047.
Galbiati V, Gibbs S, Roggen E, Corsini E. Development of an In Vitro Method to Estimate the Sensitization Induction Level of Contact Allergens. Curr Protoc Toxicol. 2018 Feb 21;75:20.15.1-20.15.20. doi: 10.1002/cptx.44.
Corsini E, Casula M, Tragni E, Galbiati V, Pallardy M. Tools to investigate and avoid drug-hypersensitivity in drug development. Expert Opin Drug Discov. 2018 May;13(5):425-433. doi: 10.1080/17460441.2018.1437141.
Galbiati V, Cornaghi L, Gianazza E, Potenza MA, Donetti E, Marinovich M, Corsini E. In vitro assessment of silver nanoparticles immunotoxicity. Food Chem Toxicol. 2018 Feb;112:363-374. doi: 10.1016/j.fct.2017.12.023.
Gibbs S, Kosten I, Veldhuizen R, Spiekstra S, Corsini E, Roggen E, Rustemeyer T, Feilzer AJ, Kleverlaan CJ. Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay. Toxicology. 2018 Jan 15;393:62-72. doi: 10.1016/j.tox.2017.10.014.
van Vliet E, Kühnl J, Goebel C, Martinozzi-Teissier S, Alépée N, Ashikaga T, Blömeke B, Del Bufalo A, Cluzel M, Corsini E, Delrue N, Desprez B, Gellatly N, Giese C, Gribaldo L, Hoffmann S, Klaric M, Maillere B, Naisbitt D, Pallardy M, Vocanson M, Petersohn D. State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop. ALTEX. 2018;35(2):179-192. doi: 10.14573/altex.1709011
Racchi M, Buoso E, Ronfani M, Serafini MM, Galasso M, Lanni C, Corsini E. Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence. Int J Mol Sci. 2017 Jul 6;18(7). pii: E1453. doi: 10.3390/ijms18071453.
Agúndez JAG, Selinski S, Corsini E, Golka K, García-Martín E. Editorial: Biomarkers in Drug Hypersensitivity. Front Pharmacol. 2017 Jun 7;8:348. doi: 10.3389/fphar.2017.00348. eCollection 2017.
Buoso E, Galasso M, Ronfani M, Papale A, Galbiati V, Eberini I, Marinovich M, Racchi M, Corsini E. The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity. Toxicol Appl Pharmacol. 2017 Jun 15;325:37-47. doi: 10.1016/j.taap.2017.04.011.
Buoso E, Galasso M, Ronfani M, Serafini MM, Lanni C, Corsini E, Racchi M. Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone. Pharmacol Res. 2017 Jun;120:180-187. doi: 10.1016/j.phrs.2017.03.019.
Corsini E, Vecchi R, Marabini L, Fermo P, Becagli S, Bernardoni V, Caruso D, Corbella L, Dell'Acqua M, Galli CL, Lonati G, Ozgen S, Papale A, Signorini S, Tardivo R, Valli G, Marinovich M. The chemical composition of ultrafine particles and associated biological effects at an alpine town impacted by wood burning. Sci Total Environ. 2017 Jun 1;587-588:223-231. doi: 10.1016/j.scitotenv.2017.02.125.
Buoso E, Galasso M, Serafini MM, Ronfani M, Lanni C, Corsini E, Racchi M. Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging. Cell Signal. 2017 Jul;35:264-271. doi: 10.1016/j.cellsig.2017.02.010
Galbiati V, Papale A, Marinovich M, Gibbs S, Roggen E, Corsini E. Development of an in vitro method to estimate the sensitization induction level of contact allergens. Toxicol Lett. 2017 Apr 5;271:1-11. doi: 10.1016/j.toxlet.2017.01.016.
Kavasi RM, Berdiaki A, Spyridaki I, Corsini E, Tsatsakis A, Tzanakakis G, Nikitovic D. HA metabolism in skin homeostasis and inflammatory disease. Food Chem Toxicol. 2017 Mar;101:128-138. doi: 10.1016/j.fct.2017.01.012.
Corsini E, Ozgen S, Papale A, Galbiati V, Lonati G, Fermo P, Corbella L, Valli G, Bernardoni V, Dell'Acqua M, Becagli S, Caruso D, Vecchi R, Galli CL, Marinovich M. Insights on wood combustion generated proinflammatory ultrafine particles (UFP). Toxicol Lett. 2017 Jan 15;266:74-84. doi: 10.1016/j.toxlet.2016.12.005.
Grants in the last 5 years:
- Ongoing project: EFSA - Case Studies NAMS_PFAS Immunotox” (Ref. OC/EFSA/SCER/2021/13)
- EU project PARC – Partnership for the Assessment of Risks from Chemicals (Unit member)
- Ongoing National project: PRIN2017: 'Endocrine disruptors: investigation of the effects on the immune and nervous systems (EDoNIS)'. Ref N. 2017MLC3NF
- Ongoing EU project, H2020-WIDESPREAD-2020-5 'Twinning towards excellence in alternative methods for toxicity assessment (TWINALT)'. Project N. 952404.
- 2016-2021: ‘Understanding allergen potency: role of protein kinase C activation in the vigor of dendritic cell activation’. Project N.2016-04
- 2018: Research grant sponsored by Aubios In vitro evaluation of Sarracenia skin tolerability and repair capacity to support the activity of Sarracenia.
Appointments in the last 5 years:
- Current EFSA Involvements:
- Hearing Expert - SCIENTIFIC COMMITTEE Panel Experts (2018-2024)
- Member - WG/P/CEP/2018/03 - WG on BPA re-evaluation
- Member - WG/P/CEP/2020/02 - WG on preparation for re-evaluation of phthalates, structurally similar substances and replacement substances
- Member - WG/U/PREV/2021/01 - Glyphosate Peer Review - Renewal Assessment
- 2022-2027: Member of the ECVAM Scientific Advisory Committee (ESAC)
- 2020-: Member of IL-2 LTT Luc assay validation management team as test system, validation and immunotoxicity expert and EURL-ECVAM liaison, validation study coordinated by JaCVAM (NIHS) for the in vitro identification of substances with immunosuppressive activity, Japan (ongoing)
- 2020-2021: Member at EFSA of the Working Group on TiO2 (ended)
- 2019-2022: Member of the working group that prepared a Detailed Review Paper on 'In vitro immunotoxicity testing' for the OECD, currently under discussion among member states. (ended)
- 2019-202 Member of the ECVAM Scientific Advisory Committee (ESAC). Documents published: ‘Replacements for animal-derived antibodies’; ‘Endocrine disruption – AR-CALUX test method’; ‘Bioelution assay’; and ‘Scientific Validity of the GARDskin and GARDpotency Test Methods’. (renewed)
- 2019-2022: Member of the IL-1 Luc assay validation management team as test system, validation and immunotoxicity expert and EURL-ECVAM liaison, validation study coordinated by JaCVAM (NIHS) for the in vitro identification of substances with immunosuppressive activity, Japan. (ended)
- 2016-2018: Member of the IL-2 Luc assay validation management team as a test system, validation and immunotoxicity expert and EURL-ECVAM liaison, validation study coordinated by JaCVAM (NIHS) for the in vitro identification of immunosuppressive substances, Japan. The method is under discussion at the OECD. (ended)
|