The impact of inhalation toxicity from environmental chemicals is a global public health concern. The World Health Organization estimates that more than seven million deaths annually can be attributed to ambient air pollution, and although regulations associated with the Clean Air Act have...
For those of us in the risk assessment arena, deriving health reference values with a classic animal-based approach is part skill and part habit, honed by years of scouring in vivo studies to identify critical health effect endpoints, executing dosimetric conversions to deduce human equivalent...
Safety assessments are important. The process of evaluating human, animal, and environmental toxicity data is crucial for regulators, researchers, and companies that sell chemicals or biologics. The speakers for the 2018 Annual Meeting and ToxExpo Symposium Session “Application of Data from New...
Americans have only gotten bigger and fatter over time. Statistics show that up to 30 percent of the adult American population is now classified as obese. Yet, a simple question remains unanswered: how did we get so fat? The most basic macro-level explanation is that not only did food production...
The topic of uncertainty could easily be one of the most controversial yet relevant conversations in the field of toxicology currently. The 2018 Continuing Education course entitled “Uncertainty Characterization in 21st-Century Toxicology: Current Practice and Practical Methods Supporting...
The trend of shifting toxicology testing from animal testing to alternative methods has penetrated all subfields in toxicology and all geological regions. The 2018 Continuing Education course “Consumer Products Safety Assessment: Progress in the Use of Alternatives to Animal Models” focused on...
On Sunday March 12, 2018, I attended the very informative Continuing Education (CE) course "Lead Optimization of Therapeutic Small Molecules: From Drug Target to Clinical Candidate Selection—Strategies and Decision Making," endorsed by SOT Drug Discovery Toxicology, Cardiovascular Toxicology,...
The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Organs-on-a-Chip, Tissue Bioprinting, and 3D Cultures: Next Generation Models for Toxicology in the 21st Century." Over the past few years, a number of new and exciting technologies have been developed for toxicity...
The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Opportunities for Read-Across Development and Application Using QSAR Approaches." As recently as 25 years ago, applying read-across techniques to predict the toxicity of a target chemical was rare. Trailblazers in...
The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Modernizing Toxicological Risk Assessment for Compounds Released from Pharmaceutical, Consumer, Medical Device, and Combination Products: Alternative Tools and Methods." For many of us working in the extractables...
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