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Advent of New In Vitro Testing Techniques Providing Insight into Inhalation Toxicity

The impact of inhalation toxicity from environmental chemicals is a global public health concern. The World Health Organization estimates that more than seven million deaths annually can be attributed to ambient air pollution, and although regulations associated with the Clean Air Act have...

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Efforts Underway to Mine Big Data for Better Safety Assessments

Safety assessments are important. The process of evaluating human, animal, and environmental toxicity data is crucial for regulators, researchers, and companies that sell chemicals or biologics. The speakers for the 2018 Annual Meeting and ToxExpo Symposium Session “Application of Data from New...

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Read-Across Uncertainties in Risk Assessments: NAM to the Rescue!

For those of us in the risk assessment arena, deriving health reference values with a classic animal-based approach is part skill and part habit, honed by years of scouring in vivo studies to identify critical health effect endpoints, executing dosimetric conversions to deduce human equivalent...

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A Toxicological Perspective on How We Became So Fat

Americans have only gotten bigger and fatter over time. Statistics show that up to 30 percent of the adult American population is now classified as obese. Yet, a simple question remains unanswered: how did we get so fat? The most basic macro-level explanation is that not only did food production...

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Bird's-Eye View of Accepting Uncertainty in the 21st Century

The topic of uncertainty could easily be one of the most controversial yet relevant conversations in the field of toxicology currently. The 2018 Continuing Education course entitled “Uncertainty Characterization in 21st-Century Toxicology: Current Practice and Practical Methods Supporting...

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Advances in Read-Across and Challenges Yet to Be Overcome

The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Opportunities for Read-Across Development and Application Using QSAR Approaches." As recently as 25 years ago, applying read-across techniques to predict the toxicity of a target chemical was rare. Trailblazers in...

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Novel In Vitro Approaches to Investigating Chemical-Induced Injury: State-of-the-Science and Applicability to Predicting Adverse Health Events in Humans

The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Organs-on-a-Chip, Tissue Bioprinting, and 3D Cultures: Next Generation Models for Toxicology in the 21st Century." Over the past few years, a number of new and exciting technologies have been developed for toxicity...

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Incorporating Systematic Review, AOPs, and Emerging Risk Methods into the Safety Assessment Process

The following blog pertains to the 2017 SOT Annual Meeting Scientific Session "Modernizing Toxicological Risk Assessment for Compounds Released from Pharmaceutical, Consumer, Medical Device, and Combination Products: Alternative Tools and Methods." For many of us working in the extractables...