The May 2025 issue of Toxicological Sciences includes a Contemporary Review that emphasizes that cadmium exposure may be an overlooked risk factor for osteoporosis, while an In-Depth Review explores the pivotal role of epidermal growth factor receptor signaling in placental development and function. A Forum article evaluates the influence of different platforms on PBPK workflow, parameters selection, and output results. Additionally, two Research Briefs are featured: One explores chronic exposure to naphthalene vapor, while the other explores exposure to perfluorohexane sulfonate. Finally, two #ToxSpotlight articles are featured: One enables regulatory scientists from different international purviews to utilize efficient approaches for prospective chemical management, while the other provides a proof of concept evaluating the utility of the US Tox21 high-throughput screening approach to assess the hazard of chemical mixtures using two estrogen receptor assays.