Blogs

Other papers in the August 2025 issue (sorted by topic category) are: 

Biotransformation, Toxicokinetics, and Pharmacokinetics
“Bayesian Refinement of a Physiologically Based Pharmacokinetic Model for Ethylbenzene Pharmacokinetics in Mice, Rats, and Humans”  

Computational Toxicology and Databases
“Quantitative and Qualitative Concordance Between Clinical and Nonclinical Toxicity Data” 

 Developmental and Reproductive Toxicology
“Developmental Exposure to 1,4-Dioxane, a Volatile Organic Compound of Emerging Concern, Induces Immediate Phenotypic, Transcriptomic, and Adult-Onset Neurodevelopmental Effects”  

“Nicotinamide Mononucleotide Ameliorates Impaired Testicular Spermatogenesis in Uranium-Exposed Mice by Modulating Glycolytic Pathways”  

Emerging Technologies, Methods, and Models
“Incorporating Metabolic Competence into High-Throughput Profiling Assays” 

“Integrating Network Analysis and Machine Learning to Elucidate Chemical-Induced Pancreatic Toxicity in Zebrafish Embryos” (open access) 

Endocrine Toxicology
“Interference with Systemic Negative Feedback as a Potential Mechanism for Nonmonotonic Dose-Responses of Endocrine-Disrupting Chemicals” 

Environmental Toxicology
“Environmental Exposome Meets Muscle Wasting: Unraveling the VOC-Sarcopenia Nexus Through Urinary Metabolomics, Inflammatory Mediation, and Network Pharmacology in the NHANES Cohort”  

“Perfluorooctane Sulfonate Exposure and Alcohol-Associated Liver Disease Severity in a Mouse Chronic-Binge Ethanol Feeding Model” 

Genetic and Epigenetic Toxicology
“Integration of the Rat Liver Micronucleus Assay into a 28-Day Treatment Protocol: Testing the Genotoxicity of 4 Small-Molecule Nitrosamines with Different Carcinogenic Potencies and Tumor Target Specificities” 

Immunotoxicology
“Elucidating CD4+ and CD8+ T-Cell Involvement in Patients with Vancomycin-Induced DRESS” 

Organ Specific Toxicology
“Dual Inhibition of TGFb2,3 Is Severely Toxic, Whereas Selective Inhibition of TGFb1, 2, or 3 and Dual Inhibition of TGFb1,2 Is Generally Tolerated in Mouse and Cynomolgus Monkey Toxicology Studies” 

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