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ToxSci October 2025 Issue Available

By James Luyendyk posted 10-09-2025 11:08 AM

  
October 2025 ToxSci cover

The October 2025 issue of Toxicological Sciences includes a two-part In-Depth Reviewthat takes a deep dive into chemosensory tobacco product toxicology. A Systematic Review discusses the potential developmental and reproductive toxicity of microplastics, while a Forum article explores de-risking seizure liability. Additionally, one #ToxSpotlight article explains a novel AI framework for enhanced in vitro to in vivo extrapolation (IVIVE) of toxicogenomics data, while another talks about a preclinical species liver chip model that provides novel understanding of in vitro to in vivo translation of ABT-288 dog liver toxicity. 

Other papers in the October 2025 issue (sorted by topic category) are: 

Biomarkers
“Characterizing Oxidative Metabolites of 6-Methylnicotine (6MN; aka Metatine): Divergent Metabolism from Nicotine and Identification of Urinary Biomarkers of Exposure”  

Biotransformation, Toxicokinetics, and Pharmacokinetics
“Characterizing Variability and Uncertainty for Parameter Subset Selection in PBPK Models” 

“Refining High-Throughput In Vitro–In Vivo Extrapolation Modeling Through Incorporation of Intestinal Toxicokinetics” 

Developmental and Reproductive Toxicology
“Targeted RNA-Sequencing of Testes from Fetal Rats Exposed to Dicyclohexyl Phthalate Informs Potency and Adverse Outcome Pathway Development” 

Endocrine Toxicology
“High-Content Imaging and Transcriptomic Analyses of the Effects of Bisphenol S and Alternative Color Developers on KGN Granulosa Cells” (open access)  

“Orthogonal Screening for Thyroid Stimulating Hormone Receptor Modulators in Human Thyroid Assays”  

Neurotoxicology
“Environmentally Relevant Lead Exposure Impacts Gene Expression in SH-SY5Y Cells Throughout Neuronal Differentiation” 

“Perfluorooctanesulfonic Acid (PFOS) Antagonizes Gamma-Aminobutyric Acid (GABA) Receptors in Larval Zebrafish and Mammalian Models” (open access) 

“Preimplantational Ethanol Exposure Causes Disturbances in Gene Expression and Abnormalities in Cerebral Cortex Morphogenesis and Behavior” (open access) 

Organ-Specific Toxicology
“Evaluating the Role of Alveolar Macrophages in Tolerance to Ozone” (open access) 

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time. 


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