The November 2025 issue of Toxicological Sciences includes a Contemporary Review that explains how new approach methodologies (NAMs) are gaining increased popularity for toxicological testing and even mechanistic research. An In-Depth Review underscores the need for targeted studies that address how common co-exposures to PFAS and alcohol may intensify liver pathology, the value of a systems biology approach for future investigations, and the importance of implementing strategies to mitigate these synergistic hazards. A Forum article shows how toxicology is shifting toward predictive, mechanism-based approaches that support quicker, more human-relevant risk assessments and reduce reliance on animal testing. Two ToxPoint articles talk about the case for equilibrative nucleoside transporters in current regulatory guidance and the indispensable role of zebrafish as a NAM. Additionally, one #ToxSpotlight article’s findings provide a foundation for understanding the reproductive toxicity of PFAS across exposure scenarios, while another suggests that PAD4 affects liver injury uniquely, depending on the stage of disease and that mechanisms of NET formation may occur independent of PAD4 in chronic liver injury.
Other papers in the November 2025 issue (sorted by topic category) are:
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