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ToxSci December 2025 Issue Available

By James Luyendyk posted 18 days ago

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The December 2025 issue of Toxicological Sciences includes an Editorial that highlights some recent adjustments made to Toxicological Sciences in an ever-changing publication landscape. One In-Depth Review highlights the current limitations and emerging opportunities in male reproductive in vitro models, providing a roadmap for integrating these systems into toxicology testing and drug development workflows, while another In-Depth Review evaluates key features of bone biology impacted by therapeutics and describes techniques for assessing bone toxicity during drug development. A Forum Article discusses the strategy of the ‘Omics for Assessing Signatures for Integrated Safety (OASIS) Consortium. Additionally, a #ToxSpotlight article explains how researchers created a diverse and strategically selected chemical library designed specifically for high-throughput toxicity testing within the PrecisionTox framework.  

Editorial: “Streamlined Format for Toxicological Sciences: Still Your Science, Your Journal” (free to read)

In-Depth Review and ToxSpotlight Article: “In Vitro Models of the Male Reproductive System: Applications for Developmental and Reproductive Toxicology”

In-Depth Review: “Investigation of Bone Toxicity in Drug Development: Review of Current and Emerging Technologies”

Forum Article: “The OASIS Consortium: Integrating Multi-omics Technologies to Transform Chemical Safety Assessment” (open access)

ToxSpotlight Article: “The PrecisionTox Chemical Library: Creation of a Chemical Collection to Discover Evolutionary Conserved Biomolecular Signatures of Toxicity” (open access; topic category: emerging technologies, methods, and models)

 Other papers in the December 2025 issue (sorted by topic category) are: 

Biomarkers
“TGx-DDI (Toxicogenomic DNA Damage-Inducing) Biomarker Validation: Multi-site Ring Trial Supporting Regulatory Use” (open access) 

Biotransformation, Toxicokinetics, and Pharmacokinetics
“Pharmacokinetics of Cannabidiol and Its Metabolites in Rhesus Monkeys and New Zealand White Rabbits” 

 Clinical and Translational Toxicology
“The Endothelial Growth Factor Angiopoietin-2 Is an Accurate Prognostic Biomarker in Patients with Acetaminophen-Induced Acute Liver Failure” 

Computational Toxicology and Databases
“Beyond QSARs: Quantitative Knowledge–Activity Relationships (QKARs) for Enhanced Drug Toxicity Prediction” (open access) 

Developmental and Reproductive Toxicology
“High-Content Toxicological Profiling of 87 Compounds Using a 3D Mouse Mini-testis Model: A New Approach Methodology (NAM) for Prioritizing Male Reproductive Toxicants” 

Emerging Technologies, Methods, and Models
“Cell Painting in HepaRG Cells: An Interlaboratory Reproducibility Study” 

Endocrine Toxicology
“Toxicological Profile of Chemical Interference of Thyroid Hormone Metabolism via Deiodinase Enzymes in a Rodent Model”  

Environmental Toxicology
“Zebrafish Cell Lines and High-Throughput Transcriptomics: Advancing In Vitro and Bioinformatics Methods for Supporting Environmental Risk Assessment” (open access) 

Nanotoxicology
“Contribution of Particle-Induced Lysosome Membrane Permeabilization to NLRP3 Inflammasome Activation and Mitochondrial ROS Production” (open access) 

“The Differential Toxicity of Three Different Oxidized Nickel Compound Nanoparticles and the Effects of Particle Surface Ligands in Mouse Alveolar Macrophages” (open access) 

Organ Specific Toxicology
“Advanced Cardiotoxicity Profiling Using Field Potential Imaging with UHD-CMOS-MEA in Human iPSC-Derived Cardiomyocytes” (open access) 

Regulatory Science, Risk Assessment, and Decision-Making
“Exploration of Oxidative Stress–Mediated Genetic Toxicology Modes of Action Using a Pathway Analysis, Connectivity Mapping, and Transcriptional Benchmark Dosing-Based Framework” 

Remember that electronic access to ToxSci articles is a benefit for Full and Associate members—use your SOT credentials to log in and view ToxSci articles. Other membership types can request discounted access to ToxSci at any time. 