Per- and polyfluoroalkyl substances (PFAS) are a major focus of environmental toxicology due to their persistence, widespread exposure, and potential impacts on early development. At the 65th SOT Annual Meeting and ToxExpo in San Diego, a Symposium S ession titled “ Developmental PFAS Toxicity: Leveraging Zebrafish as a Model for Phenotypic, ’ Omics, and Organ-Level Studies ” highlighted how zebrafish models are advancing mechanistic understanding of PFAS toxicity. Presentations by Drs. Alicia Timme-Laragy, Subham Dasgupta, Jennifer Freeman, Nishad Jayasundara, and Drake Phelps illustrated how phenotypic screening, transcriptomics, ...